Preheat your oven to 350°F (175°C). Lightly grease a loaf pan or line it with parchment paper.
In a large bowl, combine the ground beef, ground turkey, breadcrumbs, milk, eggs, chopped onion, minced garlic, Worcestershire sauce, salt, and pepper. Mix gently until just combined. Do not overmix.
Press the meat mixture evenly into the prepared loaf pan.
In a small bowl, whisk together the ketchup, brown sugar, and Dijon mustard for the glaze. Spread this mixture evenly over the top of the meatloaf.
Bake for 60-75 minutes, or until the internal temperature reaches 160°F (71°C) and the glaze is caramelized.
Let the meatloaf rest for 10 minutes before slicing and serving.
Notes
This savory meatloaf is delicious served with mashed potatoes and a side of vegetables.